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Handsearching had best recall but poor efficiency when exporting to a bibliographic tool: case study

Objectives: The objective of this study was to compare the effectiveness and efficiency of methods used to identify and export conference abstracts into a bibliographic management tool. Study Design and Setting: This is a case study. The …

Cost-effectiveness of the Manchester approach to identifying Lynch syndrome in women with endometrial cancer

Lynch syndrome (LS) is a hereditary cancer syndrome responsible for 3% of all endometrial cancer and 5% in those aged under 70 years. It is unclear whether universal testing for LS in endometrial cancer patients would be cost-effective. The …

The Tribulations of Trials: Lessons Learnt Recruiting 777 Older Adults Into REtirement in ACTion (REACT), a Trial of a Community, Group-Based Active Aging Intervention Targeting Mobility Disability

Challenges of recruitment to randomized controlled trials (RCTs) and successful strategies to overcome them should be clearly reported to improve recruitment into future trials. REtirement in ACTion (REACT) is a United Kingdom-based multicenter RCT …

The predicted impact and cost-effectiveness of systematic testing of people with incident colorectal cancer for Lynch syndrome

Objectives: To evaluate the health impact and cost-effectiveness of systematic testing for Lynch syndrome (LS) in people with incident colorectal cancer (CRC) in Australia. Design, setting, participants: We investigated the impact of LS testing …

The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome

Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The …

A New Method for Model-Based Health Economic Evaluation Utilizing and Extending Moment-Generating Functions

Health economic evaluations frequently include projections for lifetime costs and health effects using modeling frameworks such as Markov modeling or discrete event simulation (DES). Markov models typically cannot represent events whose risk is …

Three biomarker tests to help diagnose preterm labour: a systematic review and economic evaluation

Cost-effectiveness analysis of reflex testing for Lynch syndrome in women with endometrial cancer in the UK setting

Background Lynch syndrome is a hereditary cancer syndrome caused by constitutional pathogenic variants in the DNA mismatch repair (MMR) system, leading to increased risk of colorectal, endometrial and other cancers. The study aimed to identify the …

Do we know enough about the effect of low-dose computed tomography screening for lung cancer on survival to act? A systematic review, meta-analysis and network meta-analysis of randomised controlled trials.

Background: Diagnosis of lung cancer frequently occurs in its later stages. Low-dose computed tomography (LDCT) could detect lung cancer early. Methods: Our objective was to estimate the effect of LDCT lung cancer screening on mortality in high-risk …

Low-dose computed tomography for lung cancer screening in high-risk populations: A systematic review and economic evaluation

Background: Diagnosis of lung cancer frequently occurs in its later stages. Low-dose computed tomography (LDCT) could detect lung cancer early. Objectives: To estimate the clinical effectiveness and cost-effectiveness of LDCT lung cancer screening in …