Health economic modelling

Cost-effectiveness of the Manchester approach to identifying Lynch syndrome in women with endometrial cancer

Lynch syndrome (LS) is a hereditary cancer syndrome responsible for 3% of all endometrial cancer and 5% in those aged under 70 years. It is unclear whether universal testing for LS in endometrial cancer patients would be cost-effective. The …

A Trial of physical Activity assisted Reduction of Smoking (TARS)

A multi-centred, parallel, two group, randomised controlled clinical trial, with internal pilot

Advances in health economic modelling

Methodological developments including the moment-generating function method.

REACT

REtirement in ACTion: a community-based physical activity intervention to prevent mobility-related disability for retired older people.

The predicted impact and cost-effectiveness of systematic testing of people with incident colorectal cancer for Lynch syndrome

Objectives: To evaluate the health impact and cost-effectiveness of systematic testing for Lynch syndrome (LS) in people with incident colorectal cancer (CRC) in Australia. Design, setting, participants: We investigated the impact of LS testing …

A New Method for Model-Based Health Economic Evaluation Utilizing and Extending Moment-Generating Functions

Health economic evaluations frequently include projections for lifetime costs and health effects using modeling frameworks such as Markov modeling or discrete event simulation (DES). Markov models typically cannot represent events whose risk is …

Cost-effectiveness analysis of reflex testing for Lynch syndrome in women with endometrial cancer in the UK setting

Background Lynch syndrome is a hereditary cancer syndrome caused by constitutional pathogenic variants in the DNA mismatch repair (MMR) system, leading to increased risk of colorectal, endometrial and other cancers. The study aimed to identify the …

Low-dose computed tomography for lung cancer screening in high-risk populations: A systematic review and economic evaluation

Background: Diagnosis of lung cancer frequently occurs in its later stages. Low-dose computed tomography (LDCT) could detect lung cancer early. Objectives: To estimate the clinical effectiveness and cost-effectiveness of LDCT lung cancer screening in …

Economic Analysis of First-Line Treatment with Cetuximab or Panitumumab for RAS Wild-Type Metastatic Colorectal Cancer in England

Background: Combination therapies with cetuximab (Erbitux®; Merck Serono UK Ltd) and panitumumab (Vectibix®; Amgen UK Ltd) are shown to be less effective in adults with metastatic colorectal cancer who have mutations in exons 2, 3 and 4 of KRAS and …

Molecular testing for Lynch syndrome in people with colorectal cancer: Systematic reviews and economic evaluation

Background: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC), gynaecological cancers and other cancers, known as Lynch syndrome (LS). Risk-reducing interventions can …