The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome
Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients. Methods: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice. Results: Guidance was developed in four key areas: (1) whether women with gynecological cancer should be screened for Lynch syndrome and (2) how this should be done, (3) whether there was a role for gynecological surveillance in women at risk of Lynch syndrome, and (4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer. Conclusion: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.
Citation
@article{e.j.2019,
author = {Crosbie, E. J. and Ryan, N. A. J. and Arends, M. J. and
Bosse, T. and Burn, J. and Cornes, J. M. and Crawford, R. and
Eccles, D. and Frayling, I. M. and Ghaem-Maghami, S. and Hampel, H.
and Kauff, N. D. and Kitchener, H. C. and Kitson, S. J. and
Manchanda, R. and McMahon, R. F. T. and Monahan, K. J. and Menon, U.
and Møller, P. and Möslein, G. and Rosenthal, A. and Sasieni, P. and
Seif, M. W. and Singh, N. and Skarrott, P. and Snowsill, T. M. and
Steele, R. and Tischkowitz, M. and Sanchez, A. A. and Bolton, J. and
Church, D. and Donnelly, K. and Edmondson, R. J. and Evans, D. G.
and Gollop, P. and Goodman, S. and Hodgson, S. and Lalloo, F. and
Lowry, A. and McVey, R. J. and Miles, T. and Moeslein, G. and
Stormoken, A. and Stringfellow, H. and Wallace, A. and Whyte, L. and
Wilkinson, N. and Wilson, G. and Wilson, J. and Wood, N.},
title = {The {Manchester} {International} {Consensus} {Group}
Recommendations for the Management of Gynecological Cancers in
{Lynch} Syndrome},
journal = {Genetics in Medicine},
volume = {21},
number = {10},
pages = {2390-2400},
date = {2019-10-01},
url = {https://tristansnowsill.co.uk/the-manchester-international-consensus-group-recommendations.html},
doi = {10.1038/s41436-019-0489-y},
langid = {en},
abstract = {Purpose: There are no internationally agreed upon clinical
guidelines as to which women with gynecological cancer would benefit
from Lynch syndrome screening or how best to manage the risk of
gynecological cancer in women with Lynch syndrome. The Manchester
International Consensus Group was convened in April 2017 to address
this unmet need. The aim of the Group was to develop clear and
comprehensive clinical guidance regarding the management of the
gynecological sequelae of Lynch syndrome based on existing evidence
and expert opinion from medical professionals and patients. Methods:
Stakeholders from Europe and North America worked together over a
two-day workshop to achieve consensus on best practice. Results:
Guidance was developed in four key areas: (1) whether women with
gynecological cancer should be screened for Lynch syndrome and (2)
how this should be done, (3) whether there was a role for
gynecological surveillance in women at risk of Lynch syndrome, and
(4) what preventive measures should be recommended for women with
Lynch syndrome to reduce their risk of gynecological cancer.
Conclusion: This document provides comprehensive clinical guidance
that can be referenced by both patients and clinicians so that women
with Lynch syndrome can expect and receive appropriate standards of
care.}
}